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My specialty is neuroscience and physiology, but I love all sciences, athletics, healthy food and fun people.

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Neuroscience Research Techniques

 


New research out of Northwestern University shows that the circadian clock helps to control mitochondrial activity, and how efficiently cells use energy. Mitochondria regulate the amount of energy the cells use when there’s no glucose available from food, and the key compounds involved in turning on the energy burning process are NAD+ and Sirtuin 3. In a new study published in Science, the researchers found that when they removed the circadian clock genes from mice, these animals could not burn the body’s stored energy, nor did they have any reserves to prevent the depletion of ATP. This occurred because the loss of the clock genes meant cells weren’t being signaled to produce NAD+. When the researchers supplemented the mice with NAD+, the problems disappeared. The researchers hope that these findings could lead to compounds that help shift workers and others with circadian clock disruptions.Read more: http://bit.ly/1eYUqbaJournal article: Clock-Dependent NAD+ Synthesis Controls Mitochondrial Metabolism. Science, 2013. DOI:10.1126/science.1243417Image credit: barockschloss/Flickr
New research out of Northwestern University shows that the circadian clock helps to control mitochondrial activity, and how efficiently cells use energy. Mitochondria regulate the amount of energy the cells use when there’s no glucose available from food, and the key compounds involved in turning on the energy burning process are NAD+ and Sirtuin 3. In a new study published in Science, the researchers found that when they removed the circadian clock genes from mice, these animals could not burn the body’s stored energy, nor did they have any reserves to prevent the depletion of ATP. This occurred because the loss of the clock genes meant cells weren’t being signaled to produce NAD+. When the researchers supplemented the mice with NAD+, the problems disappeared. The researchers hope that these findings could lead to compounds that help shift workers and others with circadian clock disruptions.

Read more: http://bit.ly/1eYUqba
Journal article: Clock-Dependent NAD+ Synthesis Controls Mitochondrial Metabolism. Science, 2013. DOI:10.1126/science.1243417
Image credit: barockschloss/Flickr

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